Can Long-term Antibiotic Treatment Cure Autoimmune Disease?
...Doxycycline has been used successfully against chlamydia and mycoplasma in combination with Ciprofloxacin when treating victims of Gulf War Illness, where patients were found to have chronic mycoplasmal infections (2). In this case, Doxycycline (a broad-spectrum antibiotic that acts by preventing micro-organism protein synthesis) was used in combination with Ciprofloxacin (a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis). These antibiotics were administered in six-week cycles, with two-week breaks, during which Augmentin was taken; in most cases doctors found that patients required four to six treatment cycles before blood tests were negative. Azithromycin, a macrolide antibiotic, interferes with bacterial protein synthesis, and was used in cases where Doxycycline could not be tolerated, or where it had become ineffective. Clarithromycin, another macrolide, also interferes with protein synthesis, and this is also effective against a broader range of bacteria.
David Wheldon, a Cambridge microbiologist, claims to have had success using a similar combination to treat chlamydia pneumoniae infection and MS (multiple sclerosis). His regimen consists of building up treatment to a twice-daily dose of Doxycycline, thrice-weekly doses of Azithromycin, and "pulsed" cycles of Metronidazole. He particularly warns against treatment length being too short; stating that typical two to six week treatments with one antibiotic alone is likely to drive the bacteria deeper into a persistent state....http://suite101.com/a/can-long-term-antibiotic-treatment-cure-autoimmune-disease-a251760