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#310604 - 03/10/14 02:33 PM lone star tick and meat allergy
Mary Jane Offline
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Here is a very nice article plausibly linking bites from lone star ticks to allergic reactions to eating meat. The observations come from people, but I don't see why dogs might not also be affected. http://www.newyorker.com/online/blogs/elements/2014/03/can-ticks-make-you-allergic-to-red-meat.html

Any experts care to comment?

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#310605 - 03/10/14 02:55 PM Re: lone star tick and meat allergy [Re: Mary Jane]
Mary Jane Offline
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Oooops

OK, looking again it seems that the tick saliva component is a carbohydrate common to non-primate mammals, that is dogs already have the allergen. They shouldn't react to it.

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#310608 - 03/10/14 03:54 PM Re: lone star tick and meat allergy [Re: Mary Jane]
MaxaLisa Offline

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MJ, this is often discussed on the tick list, but never have I heard what you jut said about the dogs "having" it, and that's a reason why this shouldn't induce further allergens.

Can you explain further????
_________________________
MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
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#310611 - 03/10/14 04:30 PM Re: lone star tick and meat allergy [Re: MaxaLisa]
Mary Jane Offline
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Lisa, I'm almost afraid to answer, but I'll try. The (or maybe one) allergen from the tick bite that is involved in the meat reaction is Galactose-alpha-1,3-galactose. It's widespread on proteins from other mammals, including dogs and is allergenic in dog dander. Now this is not exactly about the tick bites, but IgE in people with the meat allergy cross reacts extensively with dog dander. If you remove the antibodies binding Galactose-alpha-1,3-galactose from the sera, you remove a lot of the antibodies that react with dog dander. If the allergen is in dog dander, then dogs should be tolerant to it. But there are always exceptions, I guess.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324851/

Does this make sense from the standpoint of TBD literature?

MJ

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#310658 - 03/11/14 12:16 PM Re: lone star tick and meat allergy [Re: Mary Jane]
MaxaLisa Offline

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Tick literature on this is about nil, so we are struggling to understand what this means for our dogs.

So, the idea that dogs contain this in their dander (if I understand that right) fascinates me. I must have read that before, but it flew right by because I didn't make any connections.

I do not understand this exactly, "If you remove the antibodies binding Galactose-alpha-1,3-galactose from the sera, you remove a lot of the antibodies that react with dog dander." I do not undertand if there was supposed to be an implied meaning that I missed.

There is a link between cat and pork allergies, maybe something similar - I am terribly allergic to cats, and came up allergic to pork, and lamb. Also allergic to dogs.

So, indy was allergic to cats, but not to dogs, according to her allergy test. Might that mean then that she was not allergic to this substance? Might it mean that I am since I am allergic to both? Or are there just too many possible allergens in the dander?
_________________________
MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/

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#310667 - 03/11/14 02:03 PM Re: lone star tick and meat allergy [Re: MaxaLisa]
Mary Jane Offline
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Lisa,

I'm going to try to respond in detail in case someone without your depth of knowledge is interested. You may have to skip some things.


Originally Posted By: MaxaLisa

I do not understand this exactly, "If you remove the antibodies binding Galactose-alpha-1,3-galactose from the sera, you remove a lot of the antibodies that react with dog dander."
This is the common method to identify cross-reacting antibodies. A person makes a wide variety of antibodies to several antigens in the tick saliva, here the interesting one is alpha gal. A simple way to show that the alpha gal antibodies induced by tick saliva are the same as antibodies to dog dander is by absorption. You stick the alpha gal carbohydrate on something solid like a tiny bead and expose the the person's serum to the bead. The antibodies that stick to alpha gal then stick to the bead. You then take the rest of the serum that isn't stuck to the bead and test it for binding dog dander. In this case, there were fewer antibodies binding to dog dander indicating that some of them stuck to alpha gal or cross reacted with alpha gal. Since dogs can make alpha gal and add it to different proteins, the simplest explanation is that part of the reaction to dog dander is to alpha gal.

Originally Posted By: MaxaLisa


There is a link between cat and pork allergies, maybe something similar - I am terribly allergic to cats, and came up allergic to pork, and lamb. Also allergic to dogs.

(I won't tell Jazz) Well it could be a reaction to alpha gal or it could be a reaction to any of many antigens common to those animals.

Originally Posted By: MaxaLisa

So, indy was allergic to cats, but not to dogs, according to her allergy test. Might that mean then that she was not allergic to this substance?
Indy is a different story because she shouldn't react to antigens that are common to dogs as a species and alpha gal, I believe, is common to the whole species but not primates. So probably Indy was not reacting against alpha gal but something else in most dogs but not her.


Originally Posted By: MaxaLisa

Might it mean that I am since I am allergic to both? Or are there just too many possible allergens in the dander?
You may react to alpha gal but there's not enough information to be sure.

So basically, if both people and dogs get exposed to alpha gal in tick saliva, I don't think that dogs will react as violently to meat as people, because dogs themselves make alpha gal and ought to be tolerant.

MJ


Edited by Mary Jane (03/11/14 02:08 PM)

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#310896 - 03/15/14 04:02 PM Re: lone star tick and meat allergy [Re: Mary Jane]
MaxaLisa Offline

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MJ, you give me too much credit, because I too needed all those words in order to understand smile

This is pretty interesting, definitely going to share this with the list, thank you so much!!

LOL, yes, I'm also allergic to dogs, but I seem to acclimate to their dander (though Jazz still makes me itch sometimes). Cats I don't seem to be able to tolerate over time frown I think Jazz would really like to have a cat, but it's just not going to happen!
_________________________
MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/

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