New drug for osteoarthritis

Posted by: Shilohsmom

New drug for osteoarthritis - 03/30/17 05:28 PM

Has anyone tried the new drug Galliprant? Its a new drug for the treatment of osteoarthritis and doesn't have the same side affects of like Rimidyl. I'm starting Eli on it.
Posted by: Islandgsds

Re: New drug for osteoarthritis - 03/30/17 06:27 PM

Never heard of it but I'll be looking into it asap for Larka.
Thanks for the heads up Rosa.
Posted by: Shilohsmom

Re: New drug for osteoarthritis - 03/30/17 07:27 PM

Sandra, I picked up the pups and they have both been placed on it. Apparently its really having good responses, so much so that the company is backordered on the meds. As far as price, for Eli its about $108 per month. Shoshi is smaller so it will be less but I wasn't able to get a full rx for her due to the backorder. We are hopeful that it becomes available very soon.
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/30/17 07:35 PM

It's too new to have much feedback on it yet. However, I would not use it unless your dog has been tested for the mdr1 mutation and is clear. This is the recommendation of the lab that developed the canine mdr1 test.

http://germanshepherdhome.net/forum/ubbthreads.php/topics/343163/Re:_Medications:__Galliprant#Post343163
Posted by: PositiveDog

Re: New drug for osteoarthritis - 03/30/17 07:58 PM

Buddy is in his second month on it. He is almost 17 and has a tumor on his liver.

He is 65#, and takes 60 mg once a day and it is good for him. He is more energetic and sleeping less. I credit better pain control for my old, three legged boy. (He is also on tramadol and gabepentin)

It is on back order and that should be resolved within a month according to what we've been told. The office where I work got in 3 bottles of 20 mg and we're using that this month.

I think for dogs with elevated liver #s, or liver problems in general it will prove to be valuable.

I agree with Lisa. If there is any chance of the mdr1 mutation, test first.
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/30/17 08:02 PM

So glad to hear how well Buddy is doing on it! thumbup
Posted by: Shilohsmom

Re: New drug for osteoarthritis - 03/30/17 08:17 PM

That's great news Bonnie, thanks for sharing. Eli has liver issues and undergone several tests today. Not ready to write about all that but its nice to have a good pain med for those with kidney and liver issues.
Posted by: Leslie&Chico

Re: New drug for osteoarthritis - 03/31/17 12:13 PM

I am very interested in this for Chico, thanks for the info!
I will ask the vet about it and the test for the mdr1 mutation.
Posted by: Kris

Re: New drug for osteoarthritis - 03/31/17 12:34 PM

Lisa, thank you for posting about the MDR1 gene and this drug. I was all excited about this, but now we would have to proceed carefully since Sammy does have the gene. Thankfully, right now he's just taking Glycoflex 3 supplements and doesn't need anything stronger.
Posted by: Shilohsmom

Re: New drug for osteoarthritis - 03/31/17 02:01 PM

Humm, I specifically asked my Vet about this and she said I didn't have to worry as both of my pups are purebred GSDS. Is this not true???

edit-I'm referring to the MDR1 gene.
Posted by: Kris

Re: New drug for osteoarthritis - 03/31/17 06:17 PM

Not sure what your vet meant, but 10% of German Shepherds are affected by the MDR1 gene. Purebred or mixed can have this gene. Here's a list of the breeds: http://vcpl.vetmed.wsu.edu/affected-breeds
And a list of the drugs that are a problem for an MDR1 dog: https://vcpl.vetmed.wsu.edu/problem-drugs

I would have never known Sammy had the gene until he got really sick from an Ivermectin injection right after we adopted him.
Posted by: Shilohsmom

Re: New drug for osteoarthritis - 03/31/17 06:33 PM

Originally Posted By: Kris
Not sure what your vet meant, but 10% of German Shepherds are affected by the MDR1 gene. Purebred or mixed can have this gene. Here's a list of the breeds: http://vcpl.vetmed.wsu.edu/affected-breeds
And a list of the drugs that are a problem for an MDR1 dog: https://vcpl.vetmed.wsu.edu/problem-drugs

I would have never known Sammy had the gene until he got really sick from an Ivermectin injection right after we adopted him.


OMG, heads will spin tomorrow when the hospital reopens. I can't believe this mad

Yes Kris, TEN PER CENT...I can't believe this
Posted by: Shilohsmom

Re: New drug for osteoarthritis - 03/31/17 06:38 PM

What is the testing for this MDR1 gene??? I wonder if mine were tested way back when for this????? I vaguely remember asking my old Vet about this but I don't remember much more than that....darn
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/31/17 09:02 PM

Testing is usually a cheek swab I think, but they do have a blood test now. Kris posted the link above with the most info.

IIRC, Kris' Sammie was the first non-white GSD they found with the mutation????

The drug company should be distributing this info with the drug frown
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/31/17 09:03 PM

I wonder if the lab keeps a database of every dog tested where they could look up yours?
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/31/17 09:08 PM

Originally Posted By: Kris
...And a list of the drugs that are a problem for an MDR1 dog: https://vcpl.vetmed.wsu.edu/problem-drugs


Just a side note - there are a lot of human mdr1 drugs which may or may not affect canines. Some of them have been tested, many not. With indy, I would always check to see if they affected humans if they weren,t on that list, and then went slow, or I emailed the lab. Indy was only a 1/2 mutant. People can have this too (I do wink )
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/31/17 09:11 PM

Originally Posted By: Kris
Lisa, thank you for posting about the MDR1 gene and this drug. I was all excited about this, but now we would have to proceed carefully since Sammy does have the gene. Thankfully, right now he's just taking Glycoflex 3 supplements and doesn't need anything stronger.

I specifically emailed Dr. Mealey. She recommended against it for mdr1 dogs frown I wonder if a dose modification would work, like a chihuahua size dose lol.

Does Sammie have any neurological deficits?
Posted by: Kris

Re: New drug for osteoarthritis - 03/31/17 09:47 PM

Originally Posted By: MaxaLisa


Does Sammie have any neurological deficits?


Well, not from the MDR1 gene! rofl Seriously though, once he got past the recovery after that ivermectin shot, I've never seen any lingering effects. I'm really disappointed that Dr. Mealey advises against using it. I was going to email too - thanks for getting that answer! He doesn't need it yet, but was looking forward when/if he does and thought this was a great solution. Back to the drawing board...
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 03/31/17 10:46 PM

Glad to hear about the full recovery!

Maybe by the time Sammie needs it, they will have tested it on canines. I guess they need the raw drug for testing and haven't been able to obtain it.
Posted by: Kris

Re: New drug for osteoarthritis - 03/31/17 11:45 PM

I figured since it was so new, they probably hadn't tested it yet. Thanks for info. Lisa!
Posted by: Shilohsmom

Re: New drug for osteoarthritis - 04/01/17 07:10 PM

I went down and had a nice long conversation with our Vet, the one I thought was still on vacation, and I'm feeling much better. At this point and with all the work that's been done with my pups I feel comfortable giving them this new drug. I did let her know what the other vet said about purebred GSDs not being affected by the MDR1 gene, so hopefully she is corrected on that in the future.

Gonna have more questions but will start a new thread.
Posted by: MaxaLisa

Re: New drug for osteoarthritis - 04/01/17 10:27 PM

So you have about a 90% chance your dog won't be affected. Typically, unless you specifically ask, this will not be tested for, it is not run at a regular lab.

Good luck, hope it goes well!